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Wheat & Gluten Reactivity Test– Cyrex 3x

£335.00

The wheat and gluten reactivity test can aid in identifying possible coeliac disease, non-coeliac gluten sensitivity, dermatitis herpetiformis, gluten ataxia and other wheat/gluten-related disorders. It can also be useful for assessing autoimmune reactivity associated with wheat and gluten proteins.

This is one of the most comprehensive panels available for establishing which components of wheat and gluten cause your immune system to react.

Older tests for coeliac disease and gluten sensitivity focus on just one protein –gliadin. This new test covers the whole range of proteins, peptides and enzymes involved in gluten and wheat sensitivity.

View a sample report

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Key Information

The symptoms of coeliac disease, wheat sensitivity and non-coeliac gluten sensitivity are very diverse. This can make it difficult to diagnose and it is not possible to distinguish between different gluten-related complaints on the basis of symptoms alone. Common complaints include:

  • Bloating
  • Abdominal pain
  • Fatigue
  • Diarrhoea or constipation
  • Headaches
  • Anxiety
  • Depression
  • Nausea
  • Brain fog
  • Heartburn
  • Numbness in arms and legs
  • Ataxia (lack of coordination, gait abnormality, speech changes or abnormalities in eye movements)
  • Mouth ulcers
  • Joint and muscle pain
  • Dermatitis/rashes
  • Anaemia


This test is recommended for those who present with:

  • Non-responsive digestive symptoms
  • Multiple vague symptoms such as digestive complaints, joint pain, headaches and fatigue
  • Chronic fatigue syndrome
  • Fibromyalgia
  • Depression
  • Autoimmune conditions

The wheat and gluten reactivity test measures:

  • Wheat IgA and IgG
  • Wheatgerm Agglutinin IgA and IgG
  • Native and deamidated Alpha-Gliadin-33-mer
  • Non gluten proteins A – IgA and IgG
  • Non gluten proteins B – IgA and IgG
  • Gliadin toxic peptides – IgA and IgG
  • Native and deamidated Alpha-Gliadin-33-mer – IgA
  • Native and deamidated Alpha-Gliadin-33-mer – IgG
  • Alpha-Gliadin-17-mer – IgA and IgG
  • Gamma-Gliadin-15-mer – IgA and IgG
  • Gamma-Gliadin-17-mer – IgA and IgG
  • Omega-Gliadin-17-mer – IgA and IgG
  • Glutenin-21-mer – IgA and IgG
  • Gluteomorphin and Prodynorphin IgA and IgG
  • Gliadin-Transglutaminase complex – IgA and IgG
  • Microbial Transglutaminase – IgA and IgG
  • Transglutaminase-2 IgA and IgG
  • Transglutaminase-3 IgA and IgG
  • Transglutaminase-6 IgA and IgG


This list includes proteins and enzymes that have been linked to symptoms such as brain fog, behavioural problems, mood swings, depression and other neurological complaints experienced by some gluten-sensitive people.

The Wheat and Gluten Reactivity Test is a blood test that requires a blood sample.

Recommendations for phlebotomy services will be provided after the order has been received.  Prices for these services vary depending on your location

Your sample needs to be sent using guaranteed next day delivery or via courier – (not included in price).

If you have been avoiding wheat and gluten for a while the immune response can be reduced, and it is possible to get a false negative result.

To avoid this, you should aim to reintroduce wheat and gluten a month before. For 7 days aim to eat ‘normal’ quantities such as a sandwich, piece of toast, some pasta etc.

You can arrange your blood draw for  25 – 30 days after day 7.

Immunosuppressants and steroid drugs can also reduce antibody production and cause false negative results. Please do not stop any medication without your doctor’s consent.

  1. Order Your Test with an Optional Consultation
    We will be sent your results first and will then dispatch them to you. We offer a service to interpret your results and provide you with recommendations to improve any findings within them. This requires a consultation which can be added to your order at the time of booking.
  2. Collect Your Sample at Home
    Every test comes with clear instructions on how to collect your samples.
  3. Return Your Test
    Once you’ve collected your sample, it needs to be sent using guaranteed next-day delivery or via courier (not included in price).
  4. Analysis and Result Interpretation
    Once processed, your results will be sent to us. We can then provide you with this information directly.
  5. Optional – Book a Consultation with Our Team
    Schedule a consultation with one of our team to discuss your results and develop a personalised treatment plan tailored to your needs. Our team will guide you through the findings and offer recommendations to target any of the finding in your test.
This test is processed by Cyrex Labs, by purchasing this product you are agreeing to their privacy policy

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