Intestinal permeability can lead to symptoms such as:

• Headaches
• Brain fog
• Irritable bowel
• Reactions to a wide range of foods
• Fatigue
• Joint pain
• Low mood
• Anxiety

It can also contribute to the worsening of existing inflammatory or autoimmune conditions such as rheumatoid arthritis, lupus, multiple sclerosis and psoriasis.

This test is recommended for those who:

• Regularly use gut irritants such as aspirin, ibuprofen or alcohol.
• Suffer autoimmune disease.
• Have an inflammatory digestive condition or intestinal infection.
• Present multiple symptoms such as headaches, digestive disturbance, joint pain and mood changes.
• Complain of food sensitivity and intolerance.
• Have undertaken a course of chemotherapy, radiotherapy or those on immunosuppressing medications.
• Have digestive systems and have been under a lot of stress.

The Intestinal Permeability Test measures the following antibodies:

• Occludin/Zonulin IgG
• Occludin/Zonulin IgA
• Occludin/Zonulin IgM
• Actomyosin IgA
• Lipopolysaccharides (LPS) IgG
• Lipopolysaccharides (LPS) IgA
• Lipopolysaccharides (LPS) IgM

Zonulin and occulin are proteins that open up the tight junctions of the intestinal wall, regulating how permeable the gut is. As the gut becomes inflamed and breaks down during leaky gut, the immune system makes antibodies to zonulin and occludin.

Actomyosin antibodies are an indicator of intestinal destruction. Actomyosin is a complex of proteins that make up muscle fibres and contributes to contractions in the intestine. Actomyosin antibodies indicate gut damage is severe enough to break through the cells, not just open the spaces between cells. This type of damage takes longer to repair.

The test also looks at antibodies to lipopolysaccharides (LPS). These are present in the membranes of harmful bacteria that trigger inflammation. Immune cells in the mucosal lining do not normally interact with LPS when the gut barrier is healthy. It’s only when the gut barrier becomes permeable that the immune system will see the LPS and produce antibodies. LPS antibodies also signify an overgrowth of harmful bacteria in the digestive tract.

The Intestinal Permeability Test is a blood test that requires a blood sample.

Recommendations for phlebotomy services will be provided after the order has been received.  Prices for these services vary depending on your location

Your sample needs to be sent using guaranteed next-day delivery or via courier – (not included in price).

14 working days.

Immunosuppressants and steroid drugs can reduce antibody production and cause false negative results.

Please do not stop any medication without your doctor’s consent.

3 years +

1. Order Your Test with an Optional Consultation
   We will be sent your results first and will then dispatch them to you. We offer a service to interpret your results and provide you with recommendations to improve any findings within them. This requires a consultation which can be added to your order at the time of booking.
2. Collect Your Sample at Home
   Every test comes with clear instructions on how to collect your samples.
3. Return Your Test
   Once you’ve collected your sample, simply return it to the lab by guaranteed next-day delivery or via courier. Please do not send samples on Fridays or at weekends. Price of courier is not included in the cost of the test.
4. Analysis and Result Interpretation
   Once processed, your results will be sent to us. We can then provide you with this information directly.
5. Optional – Book a Consultation with Our Team
   Schedule a consultation with one of our team to discuss your results and develop a personalised treatment plan tailored to your needs. Our team will guide you through the findings and offer recommendations to target any of the finding in your test.