This test is recommended for people who:

• Have a family history of coeliac disease and are concerned they react to gluten
• Experience digestive discomfort after eating foods such as bread, pasta and baked goods.
• Suffer from an autoimmune disease.

Many people have adverse reactions to gluten which is part of the protein found in wheat, oats, rye and barley. In extreme cases this manifests itself as coeliac disease  – an autoimmune condition where the body’s immune system attacks the small intestine in response to the ingestion of gluten. Non-coeliac gluten sensitivity is when symptoms like coeliac disease are experienced, but there is no damage to the lining of the gut.

Common symptoms include:

• Chronic diarrhoea (or constipation)
• Bulky, pale, foul-smelling stools
• Bloating
• Flatulence
• Abdominal pain
• Loss of appetite
• Weight loss

However, it can also lead to nutrient deficiencies and cause non-digestive symptoms such as:

• Anaemia
• Fatigue
• Irritability
• Depression and anxiety
• Poor growth in children
• Mouth ulcers
• A skin rash called dermatitis herpetiformis
• Muscle or joint pain
• Osteoporosis
• Fertility problems

Gluten is made of up of different types of proteins called gliadins and glutenins. In coeliacs, the gliadin is recognised by the immune system as foreign. When ingested, gliadin proteins reach the small intestine intact and are processed by an enzyme called tissue transglutaminase. This modification makes it easier for the immune system to recognise and attack the gliadin. The immune system then produces antibodies to attack the gliadin, the tissue transglutaminase enzyme and the small intestine lining. This results in inflammation and damage to this delicate absorption surface.

The coeliac and gluten sensitivity test measures the full range of different antibodies involved in non-coeliac gluten sensitivity and coeliac disease. The test includes:

• Anti-Deamidated Gliadin IgA – tests for antibodies against modified gliadin
• Anti-Endomysial IgA antibodies – tests for antibodies that attack the small intestine lining
• Anti-Tissue Transglutaminase IgA antibodies – tests for antibodies that attack tissue transglutaminase
• Anti-gliadin IgA and IgG antibodies – tests for an immune reaction to gliadin
• Total IgA – checks the immune system is function correctly and rules out the chance of a false negative test.

This test requires a blood sample from a blood draw.

After the order is received, recommendations for phlebotomy services will be provided. Prices for these services vary depending on your location.

Samples must be received at the laboratory within 24 hours of the blood draw. Do not book a blood draw Friday-Sunday.

12 working days.

For antibody testing to be accurate you need to consume gluten regularly in the run up to the test. It is recommended that you eat 1-2 portions of gluten containing foods daily for three weeks before the test.

The following medications may influence the antibody test results:

• Glucocorticoids (e.g., oral prednisone, steroid metered-dose inhaler, cortisone cream)

• Chemotherapy

• Other immunosuppressive agents (e.g., Humira, Rituxan)

• NSAIDS (e.g., Ibuprofen, Naproxen, Aspirin)

• Anticonvulsants (e.g., Carbamazepine, Valproate)

Do not stop any medication without consulting your GP or therapist.

1 year +.

1. Order Your Test with an Optional Consultation
   We will be sent your results first and will then dispatch them to you. We offer a service to interpret your results and provide you with recommendations to improve any findings within them. This requires a consultation which can be added to your order at the time of booking.
2. Collect Your Sample at Home
   Every test comes with clear instructions on how to collect your samples.
3. Return Your Test
   Once you’ve collected your sample, simply return it to the lab using the prepaid shipping label included in your kit. Your samples need to be sent guaranteed next day delivery or via courier please do not send samples on a Friday or at weekends.
4. Analysis and Result Interpretation
   Once processed, your results will be sent to us. We can then provide you with this information directly.
5. Optional – Book a Consultation with Our Team
   Schedule a consultation with one of our team to discuss your results and develop a personalised treatment plan tailored to your needs. Our team will guide you through the findings and offer recommendations to target any of the finding in your test.