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Help and Support for Endometriosis with Functional Medicine

Do you suffer from Endometriosis? Read below how Functional Medicine may be able to help you.

Endometriosis and how Functional Medicine may help

Endometriosis is a condition when the tissue that normally lines the inside of the womb (the endometrium) is found in other places in the body, for example in the Fallopian tubes or ovaries. Sometimes endometrial tissue can be found in more distant locations such as the intestines, lungs or joints.

During a normal menstrual cycle, hormonal changes cause the endometrial tissue to shed, and it exits the body through the vagina. In endometriosis, the misplaced endometrial tissue is also affected by these hormonal changes. It too starts to break down and bleed, but there is no exit route for the old tissue to leave the body. This leads to irritation, inflammation and pain as the immune system tries to clear the misplaced tissue.

The main symptoms of endometriosis include:

  • Very painful or heavy menstruation
  • Pain during sex
  • Bloating
  • Lower back pain
  • Bowel changes, especially around menstruation
  • Infertility

 

Doctors still don’t know exactly what causes endometriosis but there are a number of theories:

Some scientists have suggested that the endometrial tissue migrates backwards through the Fallopian tubes. The theory is that this can then settle elsewhere in the pelvic cavity or travel via the blood and lymph to more distant body sites.

Others have suggested that stem cells lining other body cavities or organs turn into endometrial cells. Likely under the influence of certain hormones or toxins.
In both situations there must also be altered functioning of the immune system, stopping it from recognising the misplaced tissue or from effectively removing it.

In addition to being very painful and uncomfortable, endometriosis can also lead to fertility problems. The constant inflammation around the areas of misplaced tissue can lead to the formation of scar tissue. Sometimes the scar tissue develops in a way that causes two structures to become stuck together. This is called an adhesion. These adhesions can block the passage of an egg through the Fallopian tube or cause the womb to become misaligned. Endometriosis on the ovaries can also cause the development of chocolate cysts. These are blood-filled sacs on the ovaries that can interfere with normal ovulation.

The only definitive way to diagnose endometriosis is by a laparoscopy – an operation in which a camera is inserted into the pelvis via a small cut near the navel. The surgeon uses the camera to see the pelvic organs and look for any signs of endometriosis.

There is no cure for endometriosis so medical treatment focuses on managing the symptoms

In most cases, the standard treatment for endometriosis is painkillers and hormones. Typically the oral contraceptive pill is recommended as this can make the menstrual cycle lighter and less painful. Another option is the contraceptive rod which stops the menstrual cycle completely.

In severe cases, laser surgery can be used to remove the endometrial deposits. However, it is common for endometriosis to reappear in 45% of cases.

Functional medicine takes a more holistic view of endometriosis. A typical support protocol will include steps to:

  • Balance female hormone levels and support the hormone detoxification pathways. 1
  • Support the immune system. 2
  • Work on gut health to ensure a balanced microflora as this directly influences the immune system. 3
  • Remove any foods that might be contributing to inflammation and reduced immune surveillance. 4
  • Assess any environmental exposures that might be contributing to the endometriosis. 5
  • Put in place an anti-inflammatory diet and supplement protocol. 6,7

References

  1. Rizner TL. Estrogen metabolism and action in endometriosis. Mol Cell Endocrinol. 2009 Aug 13;307(1-2):8-18. doi: 10.1016/j.mce.2009.03.022. Epub 2009 Apr 8. PMID: 19524121.
  2. Abramiuk M, Grywalska E, Małkowska P, Sierawska O, Hrynkiewicz R, Niedźwiedzka-Rystwej P. The Role of the Immune System in the Development of Endometriosis. Cells. 2022 Jun 25;11(13):2028. doi: 10.3390/cells11132028. PMID: 35805112; PMCID: PMC9265783.
  3. Elkafas H, Walls M, Al-Hendy A, Ismail N. Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders. Front Cell Infect Microbiol. 2022 Dec 16;12:1059825. doi: 10.3389/fcimb.2022.1059825. Erratum in: Front Cell Infect Microbiol. 2023 May 12;13:1211349. PMID: 36590579; PMCID: PMC9800796.
  4. Marziali M, Venza M, Lazzaro S, Lazzaro A, Micossi C, Stolfi VM. Gluten-free diet: a new strategy for management of painful endometriosis related symptoms? Minerva Chir. 2012 Dec;67(6):499-504. PMID: 23334113.
  5. Sirohi D, Al Ramadhani R, Knibbs LD. Environmental exposures to endocrine disrupting chemicals (EDCs) and their role in endometriosis: a systematic literature review. Rev Environ Health. 2020 Sep 9;36(1):101-115. doi: 10.1515/reveh-2020-0046. PMID: 32903210.
  6. Cirillo M, Argento FR, Becatti M, Fiorillo C, Coccia ME, Fatini C. Mediterranean Diet and Oxidative Stress: A Relationship with Pain Perception in Endometriosis. Int J Mol Sci. 2023 Sep 27;24(19):14601. doi: 10.3390/ijms241914601. PMID: 37834048; PMCID: PMC10572576.
  7. Amini L, Chekini R, Nateghi MR, Haghani H, Jamialahmadi T, Sathyapalan T, Sahebkar A. The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial. Pain Res Manag. 2021 May 26;2021:5529741. doi: 10.1155/2021/5529741. PMID: 34122682; PMCID: PMC8172324.

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